Guido Franceschini Selected Research

Lecithin Cholesterol Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency)

1/2017	Depletion in LpA-I:A-II particles enhances HDL-mediated endothelial protection in familial LCAT deficiency.
1/2016	Lipoprotein X Causes Renal Disease in LCAT Deficiency.
1/2016	[Lecithin:Cholesterol Acyltransferase Deficiency, from genes to therapy].
11/2013	Recombinant human LCAT normalizes plasma lipoprotein profile in LCAT deficiency.
6/2012	Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease.
5/2012	Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia.
7/2011	[LCAT deficiency: a nephrological diagnosis].
8/2009	Functional lecithin: cholesterol acyltransferase is not required for efficient atheroprotection in humans.
9/2005	The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families.
6/2004	A 33-year-old man with nephrotic syndrome and lecithin-cholesterol acyltransferase (LCAT) deficiency. Description of two new mutations in the LCAT gene.

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Guido Franceschini Research Topics

Disease

10	Lecithin Cholesterol Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency) 01/2017 - 06/2004
10	Atherosclerosis 01/2016 - 05/2002
8	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 02/2003
7	Hypoalphalipoproteinemias (Hypoalphalipoproteinemia) 11/2013 - 02/2002
4	Acute Coronary Syndrome 01/2019 - 10/2003
4	Ischemia 02/2008 - 02/2003
4	Atherosclerotic Plaque (Atheroma) 12/2006 - 05/2002
4	Reperfusion Injury 09/2006 - 02/2003
3	ST Elevation Myocardial Infarction 01/2019 - 01/2009
3	Dyslipidemias (Dyslipidemia) 01/2016 - 07/2011
3	Amyloidosis 01/2015 - 12/2006
3	Necrosis 02/2008 - 02/2003
3	Heart Neoplasms 02/2008 - 02/2003
2	Myocardial Infarction 01/2016 - 02/2013
2	Familial Amyloidosis (Hereditary Amyloidosis) 01/2015 - 06/2011
2	Hepatocellular Carcinoma (Hepatoma) 09/2013 - 03/2004
2	Hypobetalipoproteinemias (Hypobetalipoproteinemia) 05/2012 - 02/2012
2	Coronary Artery Disease (Coronary Atherosclerosis) 07/2011 - 04/2003
2	Vascular Diseases (Vascular Disease) 11/2007 - 05/2002
2	Coronary Disease (Coronary Heart Disease) 02/2007 - 05/2006
2	Myocardial Ischemia (Ischemic Heart Diseases) 09/2006 - 01/2004
1	Prostatic Neoplasms (Prostate Cancer) 01/2018
1	Hypertension (High Blood Pressure) 01/2018
1	Nephrosis 01/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2015
1	Flushing 01/2015
1	Pulmonary Embolism 02/2013
1	Venous Thrombosis (Deep-Vein Thrombosis) 02/2013
1	Ischemic Stroke 02/2013
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2012
1	Lymphoma (Lymphomas) 01/2012
1	Anemia 07/2011
1	Chronic Kidney Failure (Chronic Renal Failure) 07/2011
1	Corneal Opacity 07/2011
1	Sclerosis 07/2011
1	Rare Diseases (Rare Disease) 06/2011
1	Hyperemia 11/2007
1	Nephrotic Syndrome (Syndrome, Nephrotic) 06/2004
1	Familial Combined Hyperlipidemia (Combined Hyperlipidemia, Familial) 02/2004
1	Pathologic Processes 10/2003
1	Xanthomatosis (Xanthoma) 04/2003

Drug/Important Bio-Agent (IBA)

16	CholesterolIBA 01/2019 - 02/2002
15	HDL LipoproteinsIBA 01/2019 - 02/2003
12	HDL CholesterolIBA 01/2017 - 03/2006
9	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2015 - 05/2002
6	Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)IBA 01/2019 - 06/2004
5	LipidsIBA 01/2018 - 05/2002
4	EnzymesIBA 01/2019 - 08/2009
4	ApolipoproteinsIBA 01/2017 - 09/2002
4	Lipoproteins (Lipoprotein)IBA 01/2016 - 02/2004
3	Phospholipids (Phosphatides)FDA LinkGeneric 01/2019 - 05/2002
3	Niacin (Nicotinic Acid)FDA LinkGeneric 11/2015 - 09/2013
3	LDL CholesterolIBA 05/2012 - 08/2006
3	Creatine Kinase (Creatine Phosphokinase)IBA 02/2008 - 02/2003
3	apolipoprotein A-I MilanoIBA 11/2007 - 05/2002
2	Cell Adhesion MoleculesIBA 01/2017 - 11/2007
2	Apolipoprotein A-II (Apolipoprotein A2)IBA 01/2017 - 01/2009
2	Fenofibrate (CiL)FDA LinkGeneric 11/2015 - 09/2013
2	Pharmaceutical PreparationsIBA 01/2015 - 03/2006
2	Biomarkers (Surrogate Marker)IBA 07/2011 - 01/2009
2	Amyloid (Amyloid Fibrils)IBA 06/2011 - 12/2006
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2010 - 08/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2008 - 02/2003
2	Apoprotein(a) (Apolipoprotein (a))IBA 09/2006 - 03/2006
2	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2004 - 02/2003
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019
1	CytokinesIBA 01/2016
1	Lipoprotein-XIBA 01/2016
1	Nitric Oxide Synthase (NO Synthase)IBA 10/2013
1	Adenosine Triphosphate (ATP)IBA 09/2013
1	Fibrinolytic Agents (Antithrombotic Agents)IBA 02/2013
1	Apolipoproteins B (ApoB)IBA 05/2012
1	AutoantibodiesIBA 01/2012
1	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2009
1	Interleukin-6 (Interleukin 6)IBA 01/2009
1	Epoprostenol (Prostacyclin)FDA LinkGeneric 02/2008
1	Amino Acids FDA Link 12/2006
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 10/2006
1	DisulfidesIBA 09/2006
1	Probucol (Lorelco)FDA Link 05/2006
1	DNA (Deoxyribonucleic Acid)IBA 09/2005
1	Chymases (Chymase)IBA 03/2004
1	Scavenger Receptors (Scavenger Receptor)IBA 03/2004
1	HDL2 LipoproteinsIBA 02/2004
1	Aryldialkylphosphatase (Paraoxonase)IBA 02/2004
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 02/2004
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2004
1	Proteins (Proteins, Gene)FDA Link 01/2004
1	Dinoprostone (PGE2)FDA Link 01/2004
1	Complement System Proteins (Complement)IBA 10/2003
1	oxidized low density lipoproteinIBA 04/2003
1	Nonsense Codon (Nonsense Mutation)IBA 04/2003
1	Liposomes (Liposome)IBA 02/2003
1	ProstaglandinsIBA 02/2003
1	BuffersIBA 02/2003
1	Peptide Hydrolases (Proteases)FDA Link 09/2002

Therapy/Procedure

5	Therapeutics 01/2016 - 02/2003
3	Injections 09/2006 - 05/2002
1	Enzyme Replacement Therapy 01/2016
1	Kidney Transplantation 05/2012